AAC – Amino Acids Chemistry

Luigi Longobardo

Room 2N19; phone +39-081-674115; Email: luilongo@unina.it;

WebsiteORCIDPublications

Group website http://fco0809.blogspot.it/

 

RESEARCH LINES

1) Asymmetric synthesis

•          Novel enantioselective acylating agents

•          Enantioselective acylation of enolates

•          Chiral orthoesters in organic synthesis

 

2) Synthetic manipulation of α-amino acids

•          Homologation of α-amino acids. N-Protected β-Amino alcohols. N-Protected β-Iodo Amines. N-Protected β-3-Amino nitriles.

•          Hydrolysis-Alcoholysis of N-protected β-Amino Nitriles: β-3-amino acids.

•          Alkylation of N-(Boc) Protected β-3-Amino Nitriles: β-2,3-amino acids.

•          β-3-Amino acids containing bioactive peptides, β-casomorphine case study.

 

3) Sulfur and selenium-containing unnatural amino acids

•          CyX and Sex amino acids.

•          Orthogonally protected enantiopure S-(aminoalkyl)cysteine derivatives

•          Cystathionine and homocysteine families.

•          Proline-based unnatural amino acids.

•          Solid phase. Urotensin-II analogues with monosulfide bridges.

 

4) Chemistry of Hydroxycinnamic Acids

•          Hydroxycinnamyl alcohols with protection of phenol groups as carbonate

•          Protection and activation of hydroxycinnamic acids in water

•          Sustainable chemical derivatization of hydroxycinnamic acids

•          Improved chemical synthesis of avenanthramides family and its analogs

•          Antifungal and antibiofilm activities of 2-aminobenzoic acid derivatives