AAC – Amino Acids Chemistry

Room 2N19; phone +39-081-674115; Email: luilongo@unina.it;
Group website http://fco0809.blogspot.it/
RESEARCH LINES
1) Asymmetric synthesis
• Novel enantioselective acylating agents
• Enantioselective acylation of enolates
• Chiral orthoesters in organic synthesis
2) Synthetic manipulation of α-amino acids
• Homologation of α-amino acids. N-Protected β-Amino alcohols. N-Protected β-Iodo Amines. N-Protected β-3-Amino nitriles.
• Hydrolysis-Alcoholysis of N-protected β-Amino Nitriles: β-3-amino acids.
• Alkylation of N-(Boc) Protected β-3-Amino Nitriles: β-2,3-amino acids.
• β-3-Amino acids containing bioactive peptides, β-casomorphine case study.
3) Sulfur and selenium-containing unnatural amino acids
• CyX and Sex amino acids.
• Orthogonally protected enantiopure S-(aminoalkyl)cysteine derivatives
• Cystathionine and homocysteine families.
• Proline-based unnatural amino acids.
• Solid phase. Urotensin-II analogues with monosulfide bridges.
4) Chemistry of Hydroxycinnamic Acids
• Hydroxycinnamyl alcohols with protection of phenol groups as carbonate
• Protection and activation of hydroxycinnamic acids in water
• Sustainable chemical derivatization of hydroxycinnamic acids
• Improved chemical synthesis of avenanthramides family and its analogs
• Antifungal and antibiofilm activities of 2-aminobenzoic acid derivatives