Spin-off and patents

Spin-off

 

There are currently 3 active Spinoffs in the Department:

 

IRIDEA 

The spin-off has as its object the development, production and marketing of innovative products or services with high technological value, namely, the research, development, production, industrialization and marketing of compounds of biotechnological, biological and chemical origin relating to the pharmaceutical, biotechnological, molecular/cellular medicine, genetics and diagnostics, nutraceuticals and cosmeceuticals sectors. Accreditation date: 22/12/2020. Company incorporation date: 29/01/2021. Expiration date: 29/01/2027. Members involved: Prof. V. Pavone (Emeritus Professor), Prof. D. D'Alonzo (Associate Professor), Dr. M. De Fenza (Fixed Term Research Fellow).



DNATech   

The spin-off has as its objective the design of two molecular biology diagnostic kits for the research of the harmful yeast Brettanomyces bruxellensis found in musts and wines (Bret DNA kit and Bret Finder Kit). Accreditation date: 28/11/2017. Company incorporation date: 25/06/2018 Expiration date: 25/06/2024. DSC members involved: Prof. M. Trifuoggi (Associate Professor).


ISUSCHEM 

The aim of the initiative is to valorize the residual biomass of the forestry industry, such as vegetable oils from "no food" crops and from thermal processes in catering establishments, through the conversion of fatty acids into: - innovative solvents for cleaning agents, to formulate varnishes for printing inks, through esterification with appropriate alkomes; - eco-sustainable surfactants and plasticizing emulsifying agents, through appropriate functionalization of the double bonds present in the chain; - additives for the formulation of cosmetics. Accreditation date: 27/12/2019 Company incorporation date: 18/10/2018. Expiry date: 27/12/2025. DSC members involved: Prof. M. Di Serio (Full Professor), Prof. F. Ruffo (Associate Professor), Dr. M.E. Cucciolito (Permanent Researcher), Dr. R. Esposito (Fixed Term Research Fellow), M. Melchiorre (postDoc).

 

Patents

 

Patent Title: Identification of novel potent antioxidant compound from medicinal plant. DSC members  involved: Marina Della Greca. First filing date: 2020-07-03. Application number: TN2020000140. Grant date: 2022-04-04.

Patent Title: Catalizzatori totalmente riciclabili per reazioni di esterificazione. DSC members  involved: Maria Elena Cucciolito, Martino Di Serio, Roberto Esposito, Francesco Ruffo. First filing date: 24 January 2020. Application number: IT2020000001378. Grant date: 30 July 2020.

Patent Title: Totally recyclable catalysts for esterification reactions (WO 2021/149025 A1). DSC members  involved: Maria Elena Cucciolito, Martino Di Serio, Roberto Esposito, Francesco Ruffo. First filing date: January 25, 2021. Application number: PCT/IB2021/050551. Grant date: July 29, 2021.

Patent title: Compositions of electrolytic solutions containing solvents from renewable sources based on alpha-hydroxy acids and their combinations. DSC members involved: Martino Di Serio, Francesco Ruffo. First filing date: April 1, 2020. Application number: 102020000006766. Grant date: April 13, 2022.

Patent title: Production of a beverage rich in polyphenols obtained from grape skins taken from the maceration cap during the wine production process, subsequently dried and extracted with water using the "Naviglio Extractor. First filing date: 06/26/2017 ISSUED on 09/30/2019 Patent has no. 102017000069685. DSC teacher involved: Daniele Naviglio, NAVIGLIO OWNERSHIP: 25%. The patent is still ACTIVE to date.

Patent title: Method for the preparation of a low unspecific binding-support for affinity chromatography and/or on-line synthesis of oligonucleotides. DSC members involved: Prof. D. Montesarchio, Dr. C. Platella. First filing date: 03/20/2017. Application number 102017000030473. Grant date: 07/10/2019.

Patent title: "Hidden antibiotics in the human proteome". DSC members involved: Angela Arciello. First filing date: June 9, 2022. Application number: Application Number 63/350,815. Grant date: the patent was filed by Penn University to which I assigned the rights as owner (approval received during the department council of April 2023 and ratified by the Board of Directors). Currently the patent has been converted into a US patent (publication date February 29, 2024).

 

Other Inactive Patents:

  1. Roviello, Giuseppina; Tarallo, Oreste; Russo, Vincenzo; Di Serio, Martino; Ricciotti, Laura; Ferone, Claudio; Cioffi, Raffaele. Impiego Di Materiali Ibridi Organico-Inorganici Nell'adsorbimento Di Inquinanti Organici Emergenti 2021, 202021000002360  
  2. Balato, Giovanni; Tarallo, Oreste; Balato, Marco; Roviello, Giuseppina; Roviello, Valentina; de Matteo, Vincenzo. Impiego Di Coloranti Nell'identificazione Selettiva Di Siti Infetti Nelle Infezioni Biofilm Correlate 2020, 202020000001504  
  3. Hendriksen, Coen; Friederichs, Nicolaas Hendrika; Sainani, Jaiprakash Brijlal; Chatterjee, Anamitra; Izmer, Vyatcheslav; Kononovich, Dmitry; Voskoboynikov, Alexander; Busico, Vincenzo; Cipullo, Roberta; Vittoria, Antonio Substituted bis-2-indenyl metallocene compounds 2020, WO 2020043815A1
  4. Hendriksen, Coen; Friederichs, Nicolaas Hendrika; Voskoboynikov, Alexander; Vittoria, Antonio; Busico, Vincenzo; Cipullo, Roberta; Mladentsev, Dmitry Y.; Guzeev, Bogdan A.; Uborsky, Dmitry 1,2-PHENYLENE BRIDGED 1-INDENYL-2-INDENYL METALLOCENE COMPLEXES FOR OLEFIN POLYMERIZATION 2019, WO 2019145371 A1
  5. Friederichs, Nicolaas Hendrika; Vittoria, Antonio; Cipullo, Roberta; Busico, Vincenzo; Borisov, Ilya; Guzeev, Bogdan A.; Mladentsev, Dmitry Y.; Sharikov, Mikhail I.; Uborsky, Dmitry; Voskoboynikov, Alexander; Coen, Hendriksen Dihydrocarbyl-silyl-bridged-substituted cyclopentadienyl metallocene complexes for olefin polymerization 2018, WO 2018185176 A1
  6. Friederichs, Nicolaas Hendrika; Vittoria, Antonio; Cipullo, Roberta; Busico, Vincenzo; Borisov, Ilya; Voskoboynikov, Alexander; Guzeev, Bogdan A.; Mladentsev, Dmitry Y.; Sharikov, Mikhail I.; Uborsky, Dmitry; Coen, Hendriksen Dimethyl-silyl-bridged-1-substituted-2-indenyl metallocene complexes for olefin polymerization, polymerization of olefins and to polymers 2018, WO 2018185173 A1
  7. Friederichs, Nicolaas Hendrika; Vittoria, Antonio; Cipullo, Roberta; Busico, Vincenzo; Borisov, Ilya; Guzeev, Bogdan A.; Mladentsev, Dmitry Y.; Sharikov, Mikhail I.; Uborsky, Dmitry; Voskoboynikov, Alexander; Coen, Hendriksen Dihydrocarbyl-silyl-bridged-1,3 disubstituted-2-indenyl metallocene complexes for olefin polymerization 2018, WO 2018185170 A1
  8. Vadake Kulangara, S.; Friederichs, N. H.; Ginzburg, A.; Voskoboynikov, A.; Izmer, V.; Kononovich, D.; Samsonov, O.; Vittoria, A.; Busico, V.; Cipullo, R. Catalyst comprising a metallocene complex and a co-catalyst 2017, WO 2017/118617 A1
  9. Vadake Kulangara, S.; Friederichs, N.; Ginzburg, A.; Rongo, L.; Voskoboynikov, A.; Izmer, V.; Kononovich, D.; Samsonov, O.; Shaikh, A-A. G.; Busico, V.; Cipullo, R.; Borisov, I.; Chatterjee, A.; Uborsky, D. Catalyst comprising a metallocene complex and a co-catalyst 2016, WO 2016188999 A1. 2018, US 20180148522 A1
  10. Platella Chiara, Musumeci Domenica, Amato Jussara, Randazzo Antonio, Pagano Bruno, Montesarchio Daniela, Method for the preparation of a low unspecific binding-support for affinity chromatography and/or on-line synthesis of oligonucleotides 2018, EP3378556
  11. Roviello Antonio, Borbone Fabio, Bianco Gaetano, Coppola Giuseppe, Ferrara Maria Antonietta, Striano Valerio Materiale fotopolimerico per registrazione olografica 2019, 102016000108108
  12. Roviello, Giuseppina; Menna, Costantino; Tarallo, Oreste; Ricciotti, Laura; Ferone, Claudio; Asprone, Domenico; Colangelo, Francesco; Cioffi, Raffaele; Roviello, Antonio; Prota Andrea. Materiali Ibridi Geopolimero-Silicone Per Applicazioni Ad Alte Temperature: Metodo Di Preparazione E Materiali Cosi' Ottenuti 2016, NA2014A000027
  13. Di Fabio Giovanni; Zarrelli Armando Nuovo reagente chimico per la fosforilazione in posizione terminale di oligonucleotidi sintetici. 2016, 102015902320016
  14. Zarrelli Armando High polyphenols cocoa powder based products, uses and methods for the manufacture thereof. 2017, PCT/IB2016/053277
  15. Zarrelli Armando, Romanucci Valeria Procedimento per il trattamento di Solanacee. 2017, 102015000026250
  16. F. Auriemma, C. De Rosa, (WO 2015) Pre-polymerized catalyst components for the polymerization of olefins.
  17. Andolfi, A. Evidente (IT 2012) Composti fagodeterrenti di origine fungina.
  18. E. Bedini, A. Iadonisi  (IT 2013) Processo per la preparazione di condroitine solfatate in posizione 3 sull'acido glucuronico IT1404698
  19. E. Bedini (EP 2015) Process for obtaining chondroitin sulphated at the 4- or 6- positions of N-acetylgalactosamine residues.
  20. F. Borbone, A. Carella, R. Centore, A. Roviello, (US 2012) Procedimento di realizzazione di materiali polimerici con proprietà elettroottiche non lineari del secondo ordine e di dispositivi elettroottici realizzati con detti materiali.
  21. F. Borbone, A. Carella, A. Roviello (IT 2012) Materiale polimerico con proprietà elettroottiche non lineari del secondo ordine e dispositivi elettroottici realizzati con detto materiale.
  22. V. Busico R. Cipullo (US 2013) Activating agents for hafnium-based mtallocene compounds
  23. R. Centore, A. Roviello (IT 2011) Manufatti piezoelettrici organici ottenuti a partire da precursori liquidi di basso peso molecolare.
  24. M.E. Cucciolito, M. Di Serio, F. Ruffo, R. Tesser (IT 2014) Catalizzatori per la produzione di esteri da oli e grassi vegetali e animali.
  25. De Rosa, F. Auriemma,  O.Ruiz de Ballesteros (US 2010) Cross-point nanoarray with active anisotropic organic layer.
  26. M. Di Serio, R. Tesser (IT 2011) Nuovo processo per la produzione di acetato di etile e di idrogeno puro da etanolo.
  27. Lombardi, F. Nastri, V.Pavone (IT 2012) Catalizzatori ad alta efficienza, loro preparazione e uso.
  28. L. Paduano, G. D'Errico, D. Montesarchio (WO, 2014) Functionalized hybrid magnetite-gold nanoparticles with core-shell structure.
  29. Roviello, F. Borbone (IT 2013)Film colesterici fotostabili per la riflessione e/o la trasmissione selettiva della luce e loro uso.
  30. Roviello, F. Borbone, A. Carella (IT 2013) Politiofeni 3-sostituiti di regioregolarita' molto elevata da catalizzatori a base di rame (II).
  31. R. Tesser, M. Di Serio, (WO 2015) Thermochemical Process for Recovering Fiberglass Plastics Waste Matter
  32. R. Tesser, M. Di Serio (WO 2011) Process for the production of dichlorydrins.
  33. V. Benessere, M.E. Cucciolito, G. Dal Poggetto, M. Di Serio, M. Lega, F. Ruffo, R. Tesser, R. Turco, Catalizzatori per la produzione di esteri da oli e grassi vegetali e animali", RM2014A000763
  34. V. Benessere, M.E. Cucciolito, A. De Luca, M. Di Serio, F. Ruffo, Composizioni contenenti esteri degli acidi grassi di origine vegetale come solventi, WO 2018142320
  35. D.K. Newman, G. Kulkarni,B.J. belin, E. Giraud, A. Molinaro, A. Silipo (2019). Hopanoids producing bacteria and related biofertilizers, compositions, methods and systems US Patent 10,676,406. 20/11/2018
  36. Dello Iacono Stefania, De Nisco Mauro, De Stefano Luca, Pedatella Silvana, Serpico Luigia. Patent application n.102021000012806.Gliconiugato sintetico e membrana polimerica comprendente tale glicoconiugato. Submitted on 18/05/21.  Titolare: Avicenna Natural Institute
  37. Friederichs, Nicolaas Hendrika; Voskoboynikov, Alexander; Uborsky, Dmitry; Busico, Vincenzo; Cipullo, Roberta; Vittoria, Antonio; Sharikov, Mikhail; Kulyabin, Pavel; Nosov, Daniil Compounds for use in catalyst compositions for the production of polyolefins 2021, WO 2021052797
  38. Sainani, Jaiprakash Brijlal; Friederichs, Nicolaas Hendrika; Voskoboynikov, Alexander; Uborsky, Dmitry; Bhaumik, Kankan; Busico, Vincenzo; Vittoria, Antonio; Cipullo, Roberta; Guzeev, Bogdan; Samsonov, Oleg; Kulyabin, Pavel; Goryunov, Georgy; Yashin, Andrey; Tanwar, Akhilesh Compounds for use in catalyst compositions for the production of polyolefins 2021, WO 2021048030
  39. Vadake Kulangara, S.; Friederichs, N. H.; Ginzburg, A.; Rongo, L.; Voskoboynikov, A.; Izmer, V.; Kononovich, D.; Samsonov, O.;Shaikh, A.-A.G.; Busico, V.; Cipullo, R.; Borisov, I.; Chatterjee, A.; Uborsky, D. Catalyst comprising a metallocene complex and a co-catalyst 2018, US 2018/0148522 A1
  40. Vadake Kulangara, S.; Friederichs, N. H.; Ginzburg, A.; Voskoboynikov, A.; Izmer, V.; Kononovich, D.; Samsonov, O.; Vittoria, A.; Busico, V.; Cipullo, R. Catalyst comprising a metallocene complex and a co-catalyst 2017, WO 2017/118617 A1
  41. Vadake Kulangara, S.; Friederichs, N.; Ginzburg, A.; Rongo, L.; Voskoboynikov, A.; Izmer, V.; Kononovich, D.; Samsonov, O.; Shaikh, A-A. G.; Busico, V.; Cipullo, R.; Borisov, I.; Chatterjee, A.; Uborsky, D. Catalyst comprising a metallocene complex and a co-catalyst 2016, WO 2016/188999 A1.
  42. Busico, V.; Boone, H.; Stevens, J.; Alfano, F.; Cipullo, R.    Tactic polymer polymerization process using chiral catalysts. 2008, WO 2008/137524 A1 2012, US 8,148,482 B2.
  43. Busico, V.; Alfano, F.; Boone, H.; Cipullo, R.; Stevens, J. Multi-block copolymer process using polar solvents 2008, WO 2008/137520 A1 2012, US 8,129,487 B2.
  44. Gahleitner, M.; Ronca, S.; Van Axel Castelli, V.; Amore, M.; Cipullo, R.; Busico, V.   Compatibilised polyolefin compositions 2009, WO 2009/027516 A1.
  45. Busico, V.; Cipullo, R.; Pellecchia, R.; Razavi, A. Activating agents for hafnium based metallocene components. 2017, US 9,683,056 B2 2015, US 9,206,274 B2 2014, US 8,895,466 B2 2006, EP  1650236  A1.
  46. Razavi, A.; Busico, V.; Cipullo, R.; Cutillo, F. A polyolefin having internal double bonds and manufacture. 2005, EP 1496070  A1.
  47. Busico, V.; Guardasole, M.; Cipullo, R.; Resconi, L.; Morini, G Catalyst system for the polymerization of olefins 2008, US 2008/0132661 A1 2006, JP 2006519899 T 2005, EP 159514 2004, WO  2004/078804 A2.
  48. Ladhari, Afef; DellaGreca, Marina. Identification of novel potent antioxidant compound from medicinal plant. TN 2020000140.
  49. Melchiorre Massimo, Ruffo Francesco, Abbate Giancarlo, Di Serio Martino Composizioni di soluzioni elettrolitiche contenenti solventi da fonti rinnovabili basati su alfaidrossiacidi e loro combinazioni (Brevetto italiano N. 102020000006766)
  50. Addeo F, Caira S, Pinto G., "Preparazione di un prodotto costituito da fosfopeptidi immobilizzati su idrossiapatite per scopi nutraceutici ed (altri) innovativi" (Brevetto italiano N. N° 0001404716).