CTS- Chemistry Tools for Synthesis


Room 0Mb16; phone +39-081-674 118 Email pedatell@unina.it ;



Other Group members:

  • Dott.ssa Luigia Serpico (UNINA) – PhD student XXXIII Cycle
  • Dott.ssa Ilaria Vespoli (UNINA) –post-graduate(Master degree) Stage
  • Dott. Mauro De Nisco (UNIBAS) – visiting professor
  • Dott. Michele Manfra (UNIBAS) – visiting professor

Group web site: 



The general scientific interest of the research group lies mainly in the field of ORGANIC SYNTEHSIS, involving amino acids, sugars, and small aromatic heterocycles. We focus projects at the intersection between the discovery of the new reactions and reactivity, the development of this into powerful synthetic methodology and its application to the synthesis of molecules of biological significance. Furthermore, we aim to make our chemistry accessible to the majority of organic synthesis chemists by making the reactions technically simple to perform, efficient, scalable, selective and broad in scope.

Ongoing Projects:

  • Design and synthesis of new glycoconjugates with antioxidant activity.
  • Design and synthesis of short peptides as new β-sheet breakers.
  • Design and synthesis of new organocatalysts containing aminoacids and/or Se /Te, for enantioselective reactions in aqueous medium.

Main collaboration:

  • Prof. Claus Jacob ‐ Saarbrücken ‐ Germany Universität des Saarlandes; http://www.uni‐saarland.de/fr/lehrstuhl/jacob/mitarbeiter/professor.html
  • Prof. Stephen Hanessian – Montreal – Canada University of Montréal; http://www.hanessiangroup.com/s-hanessian.html
  • Dott. Yosef Mahajnah AVICENNA NATURAL INSTITUTE s.r.l.; www.an‐institute.it


Selected publications:

  • Gianluigi Lauro, Michele Manfra, Silvana Pedatella, Katrin Fischer, Vincenza Cantone, Stefania Terracciano, Alessia Bertamino, Carmine Ostacolo, Isabel Gomez-Monterrey, Mauro De Nisco, Raffaele Riccio, Ettore Novellino, Oliver Werz, Pietro Campiglia, Giuseppe Bifulco, ‘Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening' European Journal of Medicinal Chemistry (2017), 125, 278-287. DOI: 10.1016/j.ejmech.2016.09.042
  • Mauro De Nisco, Adele Bolognese, Marina Sala, Silvana Pedatella,* Michele Manfra*, ‘Microwave-Assisted Synthesis of Pyridophenoxazinones, a Class of Antiproliferative Compounds' ChemistrySelect (2016), 1 (6), 1292-1295. DOI: 10.1002/slct.201600316
  • Ada Nucci, Francesca Marino-Merlo, Mauro De Nisco, Silvana Pedatella, Filippo Rossi, Claus Jacob, Romualdo Caputo, Antonio Mastino, ‘Se-(2-aminoalkyl)selenocysteines as biochemical redox agents. A tool to contrast cell injury induced by aflatoxin B1 in HepG2 cells' Amino Acids (2014), 46 (2), 459-470. DOI: 10.1007/s00726-013-1639-1
  • Mauro De Nisco, Silvana Pedatella, Semiha Bektas, Ada Nucci, Romualdo Caputo ‘D-Glucosamine in a chimeric prolinamide organocatalyst for direct asymmetric aldol addition Carbohydrate Research (2012), 356, 273-277. DOI: 10.1016/j.carres.2012.03.041
  • Silvana Pedatella, Mauro De Nisco,* Domenico Mastroianni, Daniele Naviglio, Ada Nucci, and Romualdo Caputo,* Advanced Synthesis and Catalysis (2011), 353 (9), 1443-1446. DOI: 10.1002/adsc.201100143
  • Mauro De Nisco,* Silvana Pedatella, Hidayat Ullah, Javid H. Zaidi,Daniele Naviglio,Ozgur Ozdamar, and Romualdo Caputo, Proline-β3-amino-ester dipeptides as efficient catalysts for enantioselective direct aldol reaction in aqueous medium Journal of Organic Chemistry (2009), 74 (24), 9562-9565. DOI: 10.1021/jo902106r
  • Silvana Pedatella,* Mauro De Nisco, Beat Ernst, Annalisa Guaragna, Beatrice Wagner, Robert J. Woods and Giovanni Palumbo, ‘New sialyl Lewisx mimic containing an α-substituted β3-amino acid spacer Carbohydrate Research (2008), 343 (1), 31-38. DOI: 10.1016/j.carres.2007.10.001
  • Stefania Capone, Silvana Pedatella,* Annalisa Guaragna, Mauro De Nisco and Giovanni Palumbo ‘Highly diastereoselective preparation of anti-α,β-dialkyl β-amino acids containing natural α-amino acid side chains' Tetrahedron (2007), 63 (49), 12202-12206. DOI: 10.1016/j.tet.2007.09.049
  • Annalisa Guaragna, Mauro De Nisco, Silvana Pedatella and Giovanni Palumbo, ‘Studies towards lipid A: a synthetic strategy for the enantioselective preparation of 3-hydroxy fatty acids' Tetrahedron Asymmetry (2006), 17 (20), 2839-2841. DOI: 10.1016/j.tetasy.2006.10.023
  • Silvana Pedatella, Annalisa Guaragna, Daniele D'Alonzo, Mauro De Nisco, Giovanni Palumbo, ‘Triphenylphosphine polymer-bound/iodine complex: A suitable reagent for the preparation of O-isopropylidene sugar derivatives' Synthesis (2006), 2, 305-308. DOI: 10.1055/s-2005-918521
  • Stefania Capone, Annalisa Guaragna, Giovanni Palumbo and Silvana Pedatella*, ‘Efficient synthesis of orthogonally protected anti-2,3-diamino acids' Tetrahedron (2005), 61, 6575-6579. DOI: 10.1016/j.tet.2005.04.046
  • Romualdo Caputo, Pasquale Festa, Annalisa Guaragna, Giovanni Palumbo, Silvana Pedatella, ‘A novel approach to the stereocontrolled synthesis of C-vinyl β-D-galactopyranosides' Carbohydrate Research (2003), 338 (18), 1877-1880. DOI: 10.1016/S0008-6215(03)00275-1
  • Romualdo Caputo, Giuseppe Cecere, Annalisa Guaragna, Giovanni Palumbo, Silvana Pedatella, ‘β-amino-α-hydroxy esters by asymmetric hydroxylation of homo-β-amino acid esters' European Journal of Organic Chemistry (2002), (17), 3050-3054.
  • Romualdo Caputo, Horst Kunz, Domenico Mastroianni, Giovanni Palumbo, Silvana Pedatella, Francesco Solla, ‘Mild synthesis of protected α-D-glycosyl iodides' European Journal of Organic Chemistry (1999), (11), 3147-3150.
  • Romualdo Caputo, Federico Giordano, Annalisa Guaragna, Giovanni Palumbo, Silvana Pedatella, ‘A facile stereospecific synthesis of chiral β-keto sulfoxides' Tetrahedron Asymmetry (1999), 10 (18), 3463-3466. DOI: 10.1016/S0957-4166(99)00350-X
  • Romualdo Caputo, Annalisa Guaragna, Giovanni Palumbo, Silvana Pedatella, ‘A new three carbon homologation via sulfur containing heterocyclic systems' Phosphorus, Sulfur and Silicon and Related Elements (1999), 153-154, 409-410. DOI: 10.1080/10426509908546495
  • Stephen Hanessian, G.V. Reddy, H.K. Huynh, P. Jingwen, Silvana Pedatella, Beat Ernst, H.C. Kolb, ‘Design and synthesis of sialyl Le(x) mimetics based on carbocyclic scaffolds derived from (-)-quinic acid' Bioorganic and Medicinal Chemistry Letters (1997), 7 (21), 2729-2734. DOI: 10.1016/S0960-894X(97)10077-4
  • Romualdo Caputo, Annalisa Guaragna, Giovanni Palumbo, Silvana Pedatella, ‘A new and versatile allylic alcohol anion and acyl β-anion equivalent for three-carbon homologations' Journal of Organic Chemistry (1997), 62 (26), 9369-9371. DOI: 10.1021/jo9714627
  • Romualdo Caputo, Carla Ferreri, Giovanni Palumbo, Silvana Pedatella, ‘Chemistry of ethanediyl S, S-acetals 9. asymmetric synthesis of chiral cis allylic alcohols' Synthetic Communications (1995), 25 (10), 1517-1522. DOI: 10.1080/00397919508011763
  • Anna Arnoldi,. Angela Bassoli, Romualdo Caputo, Lucio Merlini, Giovanni Palumbo, Silvana Pedatella, ‘Synthesis of 3-aryl-1,4-benzoxathianes: Application to the preparation of a sweet compound' Journal of the Chemical Society, Perkin Transactions 1 (1994), 9, 1241-1244.
  • Romualdo Caputo, Carla Ferreri, Luigi Longobardo, Domenico Mastroianni, Giovanni Palumbo, Silvana Pedatella, ‘Chemistry of ethanediyl S.S-acetals 7 a stereoselective synthesis of allylic alcohols with cis-configurated double bond' Synthetic Communications (1994), 24 (9), 1223-1229 DOI: 10.1080/00397919408011721
  • Romualdo Caputo, Giovanni Palumbo, Silvana Pedatella, ‘Diastereoselective desulfurization of 5,6-dihydro-1,4-dithiins. Synthesis of muscalure from Musca domestica L.' Tetrahedron (1994), 50 (24), 7265-7268. DOI: 10.1016/S0040-4020(01)85249-2
  • Romualdo Caputo, Carla Ferreri, Luigi Longobardo, Domenico Mastroianni, Giovanni Palumbo, Silvana Pedatella, ‘A one-step synthesis of 2,3-dihydro-1,4-benzothiazines and phenothiazines from 1,3-thiazolidine derivatives of cyclohexanones' Heterocycles (1993), 36 (7), 1641-1644.
  • Romualdo Caputo, Carla Ferreri, Giovanni Palumbo, Silvana Pedatella, Francesco Russo, ‘Reactivity of ethanediyl S,S-acetals - 5. On the aromatization of the ring A in 3-oxosteroid derivatives' Heterocycles (1993), 36 (2), 281-286.