BIP – Bioinspired Products

Prof. Marco d'Ischia

Room 1Mb13; phone +39-081-674132 Email marco.dischia@unina.it ;

https://www.docenti.unina.it/marco.dischia

Prof. Alessandra Napolitano

Room 1Mb10; phone +39-081-674133 Email alessandra.napolitano@unina.it;

https://www.docenti.unina.it/alessandra.napolitano

Dr Paola Manini

Room 1Mb09; phone +39-081-674128 Email paola.manini@unina.it;

https://www.docenti.unina.it/paola.manini

Dr Lucia Panzella

Room 1Mb12; phone +39-081-674131 Email lucia.panzella@unina.it;

https://www.docenti.unina.it/lucia.panzella

Research:

1) Bioadhesion and biomimetics from Nature to applications

2) Natural and Bioinspired Polyphenols for Health and Food Applications

3) Melanins: from organic electronics to functional materials

4) Nature-inspired luminescent materials for OLED devices

 

1) Bioadhesion and biomimetics from Nature to applications

Underwater or wet adhesion is a challenging issue in biomaterials science, tissue engineering, nanomedicine, diagnostics and therapeutics, because of the increasing demand for adhesive biopolymers and coatings that can perform in adverse water or high-moisture settings. To overcome these challenges, considerable interest has been focused on the exceptional adhesion properties of mussel byssal plaque which inspired the development of polydopamine (PDA), a melanin-type adhesive biopolymer incorporating the catechol and amine structural motifs of byssal proteins. PDA, a leading model for biomimetic wet adhesion, is produced by autoxidation of dopamine at alkaline pH 8 and has been employed for surface functionalization and secondary derivatization for technological and biomedical applications. Research at UNINA –BIP group aims to translate the principles underlying mussel-inspired underwater adhesion into innovative technologies for surface functionalization and nanostructure design, with a strong commitment to the advancement of knowledge, methodological innovation and nature-inspired solutions for human health.

Main collaboration:

Professor Vincent Ball (Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1121, 11 rue Humann, Strasbourg, Cedex, France)

Dr Daniel Ruiz-Molina (Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, Spain)

Professor Gregory Payne (Institute for Bioscience and Biotechnology Research, University of Maryland, 5115 Plant Sciences Building, College Park, MD, United States)

Professor Aranzazu Del Campo (Leibniz Institute for New Materials, Campus D2 2, Saarbrücken, Germany).

 

Selected publications:

  • 1) Maria L. Alfieri, Raffaella Micillo, Lucia Panzella, Orlando Crescenzi, Stefano L. Oscurato, Pasqualino Maddalena, Alessandra Napolitano, Vincent Ball, Marco d'Ischia. Structural Basis of Polydopamine Film Formation: Probing 5,6-Dihydroxyindole-Based Eumelanin Type Units and the Porphyrin Issue. ACS Applied Materials and Interfaces (2018) 10, 7670-7680.
  • 2) Florian Ponzio, Julien Barthès, Jérôme Bour, Marc Michel, Philippe Bertani, Joseph Hemmerlé, Marco d'Ischia, Vincent Ball. Oxidant Control of Polydopamine Surface Chemistry in Acids: A Mechanism-Based Entry to Superhydrophilic-Superoleophobic Coatings. Chemistry of Materials (2016) 28, 4697-4705.
  • 3) Marianna Ambrico, Nicola Fyodor Della Vecchia, Paolo F. Ambrico, Antonio Cardone, Stefania R. Cicco, Teresa Ligonzo, Roberto Avolio, Alessandra Napolitano, Marco d'Ischia. A photoresponsive red-hair-inspired polydopamine-based copolymer for hybrid photocapacitive sensors. Advanced Functional Materials (2014) 24, 7161-7172.
  • 4) Marco d'Ischia, Alessandra Napolitano, Vincent Ball, Chun-Teh Chen, Markus J. Buehler. Polydopamine and eumelanin: From structure-property relationships to a unified tailoring strategy. Accounts of Chemical Research (2014) 47, 3541-3550.
  • 5) Nicola Della Vecchia, Roberto Avolio, Michela Alfè, Maria E. Errico, Alessandra Napolitano, Marco d'Ischia. Building-block diversity in polydopamine underpins a multifunctional eumelanin-type platform tunable through a quinone control point. Advanced Functional Materials (2013) 23, 1331-1340.

2) Natural and Bioinspired Polyphenols for Health and Food Applications

The search for novel antioxidants to be used to prevent/control food deterioration or as adjuvants in the treatment of oxidative stress based pathologies has recently spurred considerable interest. In this connection natural compounds and particularly polyphenols that can be easily obtained from accessible vegetable sources or even agricultural wastes are nowadays extensively investigated. Along these lines our research activity is directed to: 1) characterization of the properties of natural polyphenols from food or wastes for application as food supplements, food dyes, additives in food packaging, but also as functional additives for the implementation of bioactive materials e.g. for cosmetic and biomedical applications; 2) tailoring and powering these properties by bioinspired (e.g. fermentation or biomimetic oxidation) or chemical (e.g. hydrolytic treatment) transformations.

Main collaboration:

Andreas Schieber (Institute of Nutritional and Food Sciences, Chair of Molecular Food Technology, University of Bonn, Germany)

José Ángel Rufián-Henares (Departamento de Nutrición y Bromatología, Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Spain)

Luis Goya (Department of Metabolism and Nutrition, ICTAN, CSIC, Madrid, Spain)

Gregory F. Payne (Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, USA)

Thomas Eidenberger (School of Engineering and Environmental Sciences, Upper Austria University of Applied Sciences, Wels, Austria)

Kenneth Benning (Acipenser Biotech Limited, London, Great Britain)

 

Selected publications:

  • 1) Luisella Verotta, Lucia Panzella, Stefano Antenucci, Valentina Calvenzani, Federica Tomay, Katia Petroni, Enrico Caneva, Alessandra Napolitano. Fermented pomegranate wastes as sustainable source of ellagic acid: antioxidant properties, anti-inflammatory action, and controlled release under simulated digestion conditions. Food Chemistry (2018), 246, 129.
  • 2) Mariagrazia Iacomino, Fabian Weber, Maike Gleichenhagen, Valeria Pistorio, Lucia Panzella, Elio Pizzo, Andreas Schieber, Marco d'Ischia, Alessandra Napolitano. Stable benzacridine pigments by oxidative coupling of chlorogenic acid with amino acids and proteins: toward natural product-based green food coloring. Journal of Agricultural and Food Chemistry (2017), 65, 6519.
  • 3) Lucia Panzella, Pierfrancesco Cerruti, Veronica Ambrogi, Sarai Agustin-Salazar, Gerardino D'Errico, Cosimo Carfagna, Luis Goya, Sonia Ramos, Maria A. Martín, Alessandra Napolitano, Marco d'Ischia. A superior all-natural antioxidant biomaterial from spent coffee grounds for polymer stabilization, cell protection, and food lipid preservation. ACS Sustainable Chemistry & Engineering (2016), 4, 1169.
  • 4) Stefano Antenucci, Lucia Panzella, Hermes Farina, Marco Aldo Ortenzi, Enrico Caneva, Simona Martinotti, Elia Ranzato, Bruno Burlando, Marco d'Ischia, Alessandra Napolitano, Luisella Verotta. Powering tyrosol antioxidant capacity and osteogenic activity by biocatalytic polymerization. RSC Advances (2016), 6, 2993.
  • 5) Paola Manini, Lucia Panzella, Thomas Eidenberger, Antonella Giarra, Pierfrancesco Cerruti, Marco Trifuoggi, Alessandra Napolitano. Efficient binding of heavy metals by black sesame pigment: toward innovative dietary strategies to prevent bioaccumulation. Journal of Agricultural and Food Chemistry (2016), 64, 890.

3) Melanins: from organic electronics to functional materials

The imitation of Nature's structures and principles has emerged as a major competitive strategy for the design of functional materials. Natural biomaterials usually exhibit superior properties, functional efficiency and diversity normally related to their complex supramolecular architecture, which confer a variety of properties e.g. mechanical stability and ability to respond dynamically to stimuli. An outstanding and little explored source of inspiration in this frame is provided by melanins, the unique black insoluble and heterogenous pigments exhibiting key properties including: a) a broadband optical absorption throughout the entire UV-visible; b) nearly quantitative non radiative conversion of absorbed photon energy; c) photoconductivity in the solid state; d) electronic-ionic hybrid conductor properties; e) hydration-dependent free radical properties; f) metal ion-binding properties; g) redox behavior. On this basis, aim of this research line is to exploit the peculiar chemical-physical properties of melanic pigment to design innovative functional materials for technological applications.

Main collaboration:

Gianluca M. Farinola (University of Bari)

Marianna Ambrico (CNR-Istituto di Nanotecnologia – Bari)

Cinzia Chiappe (University of Pisa)

Franceso De Angelis (University of L'Aquila)

 

Selected publications:

  • 1) Martina M. Cecchini, Samantha Reale, Paola Manini, Marco d'Ischia, Francesco De Angelis. Modeling Fungal Melanin Buildup: Biomimetic Polymerization of 1,8-Dihydroxynaphthalene Mapped by Mass Spectrometry. Chemistry - A European Journal (2017) 23, 8092-8098.
  • 2) Marianna Ambrico, Paolo F. Ambrico, Teresa Ligonzo, Antonio Cardone, Maria G. Bridelli, Giuseppe Casamassima, Paola Manini, Marco d'Ischia. Hydration-controlled anisotropic and giant permittivity in TEG-functionalized eumelanin Physical Chemistry Chemical Physics (2017) 19, 9432-9443.
  • 3) Paola Manini, Piero Margari, Christian Pomelli, Paola Franchi, Gennaro Gentile, Alessandra Napolitano, Luca Valgimigli, Cinzia Chiappe, Vincent Ball, Marco d'Ischia. Nanoscale disassembly and free radical reorganization of polydopamine in ionic liquids. Journal of Physical Chemistry B (2016) 120, 11942-11950.
  • 4) Alessandro Pezzella, Mario Barra, Anna Musto, Angelica Navarra, Michela Alfè, Paola Manini, Silvia Parisi, Antonio Cassinese, Valeria Criscuolo, Marco d'Ischia. Stem cell-compatible eumelanin biointerface fabricated by chemically controlled solid state polymerization. Materials Horizons, (2015) 2, 212-220.
  • 5) Stefania R. Cicco, Marianna Ambrico, Paolo F. Ambrico, Maurizio Mastropasqua Talamo, Antonio Cardone, Teresa Ligonzo, Rosa Di Mundo, Cinzia Giannini, Teresa Sibillano, Gianluca M. Farinola, Paola Manini, Alessandra Napolitano, Valeria Criscuolo, Marco d'Ischia. A water-soluble eumelanin polymer with typical polyelectrolyte behaviour by triethyleneglycol N-functionalization. Journal of Materials Chemistry C (2015), 3, 2810-2816.

4) Nature-inspired luminescent materials for OLED devices

The rise of solid state lighting represents an important breakthrough for our society due to the very high efficiency and low energy consumption making OLED a valid alternative to fluorescent and halogen lamps. Moreover, the unique mechanical properties of OLED allowing the fabrication of flat, flexible and large area devices on different type of substrates, including glass, plastics and textile, together with the high color quality and wide color tuning achievable via selected structural changes in the organic emitters, stimulated the diffusion of OLED in different sectors, from civil lighting to automotive industry, from electronics to biomedical sector, from interior design to light art and fashion industry. The research on OLED is still active aiming at reducing the cost of production of the device and improving its efficiency and lifetime by designing more efficient electroluminescent materials and new device architectures. Starting from this background, main goal of this research line is the design, synthesis and characterization of electroluminescent materials inspired to natural compounds for OLED applications.

Main collaboration:

Maria Grazia Maglione, Paolo Tassini and Carla Minarini (Laboratory of Nanomaterials and Devices – ENEA R. C. Portici (Napoli)).

 

Selected publications:

  • 1) Paola Manini, Valeria Criscuolo, Laura Ricciotti, Alessandro Pezzella, Mario Barra, Antonio Cassinese, Orlando Crescenzi, Maria G. Maglione, Paolo Tassini, Carla Minarini, Vincenzo Barone, Marco d'Ischia Melanin-inspired organic electronics: Electroluminescence in asymmetric triazatruxenes. ChemPlusChem (2015) 80, 919-927.
  • 2) Maria G. Maglione, Salvatore Aprano, Paolo Tassini, Valeria Criscuolo, Carmela T. Prontera, Alfredo Rubino, Paola Manini, Carla Minarini. Dispositivi luminescenti OLED per applicazioni di illuminazione. Energia, Ambiente e Innovazione (2015) 61, 65-73.
  • 3) Paola Manini, Valeria Criscuolo, Maria G. Maglione, Paolo Tassini, Salvatore Aprano, Carla Minarini. Sintesi e caratterizzazione di materiali innovativi per applicazioni OLED. (2013) RdS/PAR2013/115.
  • 4) Paola Manini, Valeria Criscuolo, Emanuela Picardi, Loredana Leone, Maria G. Aufiero. I Triazatruxeni quali Nuovi Materiali Organici per Applicazioni in Dispositivi OLED: Sintesi, Caratterizzazione e Relazione Struttura-Proprietà. (2014). RdS/PAR2013/064.
  • 5) Paola Manini, Valeria Criscuolo, Carmela T. Prontera. Sintesi, Caratterizzazione e Proprietà Optoelettroniche di Complessi dell'Iridio (III) quaIi Nuovi Materiali Elettroluminescenti per Dispositivi LEECs. (2015) RdS/PAR2015.

Active grants

  • "Evaluation of cosmetic ingredients for the control of skin pigmentation" Symrise AG Holzminden, Germany
  • "Development of structure-color relationships in model eumelanin pigments and eumelanin oligomer precursors" KaoCorporation, Tokyo, JAPAN
  • "Sintesi e proprietà foto-fisiche di complessi luminescent ottenuti con leganti b-dichetonici estratti da piante della famiglia delle Zingiberaceae" Ente Nazionale per l'Energia e l'Ambiente (ENEA) centro ricerche Portici (Napoli).